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Table 3 Activated canonical pathways in LP-C comparisons

From: Transcriptional landscape of psoriasis identifies the involvement of IL36 and IL36RN

Ingenuity canonical pathways -log(p-value) Ratio
Granulocyte Adhesion and Diapedesis 19.60 0.31
Agranulocyte Adhesion and Diapedesis 12.20 0.25
Role of IL-17A in Psoriasis 10.10 0.79
Atherosclerosis Signaling 9.75 0.25
Pathogenesis of Multiple Sclerosis 9.73 0.90
Differential Regulation of Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17F 9.54 0.61
Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17F 8.91 0.67
Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza 8.38 0.39
LXR/RXR Activation 6.29 0.20
Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses 6.13 0.22
Role of Cytokines in Mediating Communication between Immune Cells 5.89 0.31
Altered T Cell and B Cell Signaling in Rheumatoid Arthritis 5.85 0.22
T Helper Cell Differentiation 5.66 0.26
Hepatic Fibrosis / Hepatic Stellate Cell Activation 5.03 0.18
Communication between Innate and Adaptive Immune Cells 4.86 0.19
IL-10 Signaling 3.95 0.21
  1. Differentially expressed genes were used as a “signature” to find what biological function is changed in the skin of psoriasis patients.