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Table 4 Activated canonical pathways in NLP-C comparisons

From: Transcriptional landscape of psoriasis identifies the involvement of IL36 and IL36RN

Ingenuity canonical pathways -log(p-value) Ratio
Role of IL-17A in Psoriasis 7.64 0.50
γ-linolenate Biosynthesis II (Animals) 4.05 0.21
Granulocyte Adhesion and Diapedesis 3.80 0.08
Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza 3.62 0.15
Atherosclerosis Signaling 3.10 0.08
Altered T Cell and B Cell Signaling in Rheumatoid Arthritis 3.09 0.09
Agranulocyte Adhesion and Diapedesis 3.02 0.07
Role of Cytokines in Mediating Communication between Immune Cells 3.02 0.13
Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17F 2.82 0.22
LPS/IL-1 Mediated Inhibition of RXR Function 2.72 0.06
Stearate Biosynthesis I (Animals) 2.51 0.10
Primary Immunodeficiency Signaling 2.44 0.09
Differential Regulation of Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17F 2.41 0.17
IL-17 Signaling 2.34 0.09
Communication between Innate and Adaptive Immune Cells 2.33 0.07
Uracil Degradation II (Reductive) 2.32 0.18
  1. Differentially expressed genes were used as a “signature” to find what biological function is changed in the skin of psoriasis patients.