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Table 2 Number of significant miRNA genomic loci

From: MicroRNAs enrichment in GWAS of complex human phenotypes

Phenotype condFDR FDR p-value
(<0.01) (<0.01) (Bonferroni)
BD 8 2 0
BMI 7 5 3
CD 55 34 16
CPD 1 0 0
HDL 52 38 18
Height 189 123 51
LDL 62 37 19
MS 51 42 25
PrCa 16 12 6
SBP 12 6 2
SCZ 29 14 6
T2D 1 1 1
TG 84 43 20
UC 54 36 18
WHR 4 3 0
  1. Comparative table showing number of identified genomic loci with conditional false discovery rate (condFDR < 0.01) compared with false discovery rate (FDR < 0.01) and standard p-value (Bonferroni correction p < 5×10−8). We show that the condFDR method improves the discovery of miRNA SNPs across the 15 phenotypes. The numbers reported here are after pruning SNPs for LD at a threshold of r2 ≤ 0.2. BD, Bipolar Disorder; BMI, Body Mass Index; CD, Crohn's disease; CPD, Cigarettes per Day; HDL, High density lipoprotein; LDL, Low density lipoprotein; MS, multiple sclerosis; PrCa, prostate cancer; SBP, systolic blood pressure; SCZ, Schizophrenia; T2D, Type 2 Diabetes; TG, triglycerides; UC, Ulcerative Colitis; WHR, Waist to Hip Ratio.