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Figure 7 | BMC Genomics

Figure 7

From: The pathogenic human Torsin A in Drosophila activates the unfolded protein response and increases susceptibility to oxidative stress

Figure 7

Down-regulation of hsc3, xbp1, ATF6 and Pek induced early death of the HTorAΔE flies. (A) When hsc3 expression was down-regulated by hsc-RNAi, it resulted in the induction of early death for the HTorAΔE flies. (B) Down-regulation of Xbp1 by mutant chromosome, xbp1 K13803 or xbp1 RNAi resulted in significantly earlier deaths among the HTorAΔE flies. (C) Decreased ATF6 in the HTorAΔE flies induced increased the HR of the HTorAΔE flies. (D) Down-regulated Pek in the HTorAΔE fly brains significantly increased the HR of the HTorAΔE flies.

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