Venn diagrams of significantly modulated genes and proteins (p-value ≤ 0.05). A549 cells (n = 3) were exposed for 24 h to increasing concentrations of fumed silica AEROSIL® 200 NPs (3.0 and 6.0 μg/cm2). A) Number of modulated genes. B) Number of modulated proteins in supernatants. More than 80% of the modulated molecules present at 3.0 μg/cm2 were also modulated at 6.0 μg/cm2 in both omics analyses.