Figure 8
Changes in the mRNA expression measured by transcriptome and by real-time PCR. The fold changes of FGA, F2, PLAU, FGG, F7, and PROC in cells treated with fumed silica AEROSIL® 200 NPs (6.0 μg/cm2 at 72 h) are expressed versus untreated cells. For qRT-PCR (n = 6) normalization was based on the total RNA mass quantified on the Nanodrop. All expressions in treated cells were significantly different from controls at p < 0.05. These genes are all connected to the “coagulation pathway” and the qRT-PCR findings confirm transcriptomic data.