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Figure 3 | BMC Genomics

Figure 3

From: Transcriptomic profiles of aging in purified human immune cells

Figure 3

Age-associated expression pattern for the Bcl-2 family and other key autophagy genes suggest autophagy declines with age. The ‘black’ co-expression network module gene - MCL1 (circle), and other key genes (diamonds) encoding autophagy machinery and autophagy inhibitors/activators (related to the Bcl-2 family and the PI3K/AKT signaling pathway) are shown, with edges representing previously characterized protein-protein interactions (STRING v9.05). Color denotes the direction and significance resulting from the association of age and gene expression in 1,264 CD14+ human monocyte samples, adjusting for race, sex, study site, and residual cell contamination with other cell types.

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