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Figure 4 | BMC Genomics

Figure 4

From: Transcriptomic profiles of aging in purified human immune cells

Figure 4

Protein functions and interactions between co-expressed genes assigned to the ‘blue’ network module. In 1,264 monocyte samples, older age was associated with lower expression of 217 co-expressed genes assigned to the ‘blue’ network module, 77 of which (shown as diamonds) have experimental evidence for interaction with other ‘blue’ module genes (interactions shown as edges, from STRING v9.1). Color denotes gene membership to Gene Ontology (GO) pathways enriched in the ‘blue’ module relative to all monocyte expressed genes (FDR < 0.05), including the electron transport chain/oxidative phosphorylation pathway (blue) and ribonucleoprotein complex pathway (green, purple, and yellow) – comprised of protein synthesis machinery genes from the mitochondrial ribosome (green), the ribosome (purple), and RNA processing genes (yellow). Genes relating to other cellular processes (white) include mitochondrial protein import genes (TOMM20, TOMM22) and DNA damage response genes (NSMCE2, SUMO2, SUMO1, TDP2); ‘blue’ module genes without reported protein-protein interactions are not shown (140 genes).

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