From: Transcriptomic profiles of aging in purified human immune cells
Age ~ Methylation | Methylation ~ cis Gene expression | Age ~ Gene expression | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
CpG ID | Chr | Cor | FDR | Gene | Cor | FDR | Indirect | Direct | Total | |||
Beta (SE) | P-value | Beta (SE) | P-value | Beta (SE) | FDR | |||||||
Oxidative phosphorylation genes from gene ontology (GO:0006119): | ||||||||||||
cg07388493 | 1 | −0.4 | 2.4E-42 | NDUFS5 | 0.22 | 1.1E-12 | −0.097 (0.014) | 2.7E-12 | −0.09 (0.03) | 1.9E-03 | −0.19 (0.03) | 1.2E-08 |
cg24704287 | 19 | −0.17 | 1.6E-07 | NDUFB7 | 0.16 | 1.3E-05 | −0.037 (0.009) | 1.8E-05 | −0.11 (0.03) | 1.8E-05 | −0.15 (0.03) | 9.4E-06 |
cg09267188 | 8 | −0.14 | 2.1E-05 | UQCRB | −0.13 | 1.1E-03 | 0.028 (0.007) | 3.7E-05 | 0.10 (0.03) | 9.3E-05 | 0.13 (0.03) | 1.0E-05 |
cg27246938 | 7 | −0.11 | 7.5E-04 | NDUFB2 | −0.24 | 2.5E-14 | 0.030 (0.007) | 6.1E-05 | −0.14 (0.03) | 1.1E-07 | −0.11 (0.03) | 1.2E-04 |
cg09876992 | 22 | −0.32 | 3.3E-26 | NDUFA6 | −0.13 | 8.5E-04 | −0.027 (0.007) | 1.8E-04 | −0.17 (0.03) | 7.2E-10 | −0.20 (0.03) | 6.9E-04 |
Ribosome genes from gene ontology (GO:005840): | ||||||||||||
cg17328880 | 19 | −0.25 | 3.4E-16 | MRPL34 | 0.29 | 4.0E-22 | −0.070 (0.01) | 7.6E-12 | −0.07 (0.03) | 4.8E-03 | −0.14 (0.03) | 3.0E-06 |
cg04865726 | 1 | −0.27 | 7.5E-19 | MRPL20 | 0.24 | 1.2E-14 | −0.069 (0.011) | 7.7E-11 | −0.12 (0.03) | 3.9E-06 | −0.19 (0.03) | 9.2E-09 |
cg08885076 | 2 | −0.2 | 8.1E-11 | MRPL30 | 0.2 | 7.6E-10 | −0.042 (0.008) | 6.9E-08 | −0.05 (0.03) | 5.3E-02 | −0.09 (0.03) | 1.1E-03 |
cg16399745 | 12 | −0.29 | 6.4E-21 | MRPL51 | −0.15 | 8.4E-05 | 0.036 (0.008) | 5.5E-06 | −0.15 (0.03) | 1.1E-08 | −0.12 (0.03) | 6.6E-05 |
cg16604233 | 6 | −0.26 | 3.0E-17 | RPS18 | −0.16 | 4.6E-06 | 0.042 (0.01) | 1.6E-05 | −0.16 (0.03) | 8.1E-08 | −0.11 (0.03) | 1.3E-04 |
cg16000022 | 11 | −0.16 | 1.8E-06 | MRPL21 | −0.15 | 4.9E-05 | 0.028 (0.007) | 2.8E-05 | 0.10 (0.03) | 1.3E-04 | 0.13 (0.03) | 6.9E-06 |
cg17614703 | 5 | 0.14 | 3.2E-05 | CANX | −0.13 | 7.7E-04 | 0.028 (0.007) | 2.9E-05 | 0.10 (0.03) | 8.2E-05 | 0.13 (0.03) | 3.2E-05 |
cg15829665 | 6 | −0.12 | 5.5E-04 | MRPL18 | −0.13 | 1.3E-03 | 0.028 (0.007) | 3.6E-05 | 0.10 (0.03) | 9.3E-05 | 0.13 (0.03) | 4.6E-05 |
cg21252105 | 9 | −0.18 | 2.8E-08 | MRPL41 | 0.15 | 4.3E-05 | −0.035 (0.009) | 7.8E-05 | −0.10 (0.03) | 2.2E-04 | −0.13 (0.03) | 2.7E-05 |
cg14663914 | 19 | −0.11 | 1.1E-03 | RPS15 | 0.17 | 1.7E-06 | −0.027 (0.007) | 8.9E-05 | −0.17 (0.03) | 1.5E-09 | −0.20 (0.03) | 6.5E-06 |
cg05017994 | 5 | 0.16 | 9.4E-07 | MRPL36 | −0.15 | 2.3E-05 | −0.039 (0.01) | 9.6E-05 | −0.14 (0.03) | 3.2E-07 | −0.18 (0.03) | 1.9E-07 |
cg23163653 | 6 | −0.16 | 3.8E-07 | ABCF1 | −0.13 | 6.2E-04 | −0.027 (0.007) | 1.0E-04 | −0.17 (0.03) | 1.2E-09 | −0.20 (0.03) | 1.3E-03 |
cg10700019 | 8 | −0.11 | 9.8E-04 | RPL8 | −0.28 | 5.2E-21 | 0.033 (0.008) | 1.1E-04 | 0.12 (0.03) | 7.7E-06 | 0.15 (0.03) | 1.0E-05 |
cg27209993 | 6 | −0.14 | 2.7E-05 | MRPS10 | 0.17 | 4.0E-07 | −0.023 (0.006) | 1.3E-04 | −0.06 (0.03) | 2.7E-02 | −0.09 (0.03) | 1.1E-03 |
cg00435173 | 17 | −0.2 | 3.7E-10 | RPL27 | 0.13 | 1.1E-03 | 0.033 (0.009) | 1.4E-04 | 0.12 (0.03) | 4.8E-06 | 0.15 (0.03) | 8.0E-04 |
cg00530414 | 16 | −0.21 | 8.3E-12 | RPS15A | −0.15 | 3.9E-05 | 0.030 (0.008) | 1.8E-04 | −0.13 (0.03) | 5.0E-06 | −0.09 (0.03) | 1.0E-03 |
cg22803868 | 17 | −0.12 | 6.1E-04 | NUFIP2 | −0.14 | 2.0E-04 | 0.023 (0.007) | 4.7E-04 | 0.11 (0.03) | 8.8E-05 | 0.13 (0.03) | 7.1E-05 |
cg13084677 | 4 | 0.12 | 3.8E-04 | RPL9 | 0.19 | 3.5E-09 | 0.017 (0.006) | 4.6E-03 | −0.12 (0.03) | 1.8E-05 | −0.10 (0.03) | 7.7E-04 |
Autophagy genes from Figure 3 : | ||||||||||||
cg24213719 | 18 | 0.19 | 1.9E-09 | BCL2 | 0.13 | 7.2E-04 | 0.028 (0.007) | 3.3E-05 | 0.10 (0.03) | 1.4E-04 | 0.13 (0.03) | 1.2E-03 |
cg11789534 | 22 | −0.17 | 1.3E-07 | IL2RB | 0.16 | 4.1E-06 | −0.032 (0.008) | 4.6E-05 | 0.09 (0.02) | 4.2E-05 | 0.06 (0.02) | 9.9E-04 |
cg21826784 | 1 | −0.12 | 3.4E-04 | FRAP1 | −0.13 | 9.5E-04 | −0.027 (0.007) | 1.2E-04 | −0.17 (0.03) | 2.2E-09 | −0.20 (0.03) | 2.3E-05 |
cg22117188 | 3 | −0.13 | 1.4E-04 | PRKCD | −0.18 | 1.9E-07 | −0.027 (0.007) | 1.5E-04 | −0.17 (0.03) | 5.2E-10 | −0.20 (0.03) | 8.6E-05 |
cg18728264 | 11 | −0.19 | 1.9E-09 | IL10RA | 0.14 | 3.9E-04 | −0.020 (0.006) | 4.3E-04 | 0.21 (0.03) | 1.7E-13 | 0.19 (0.03) | 1.5E-08 |