Comparison of the predicted proteomes of D. noxia and seven additional arthropod species. A. Maximum-likelihood phylogeny generated from concatenated MUSCLE alignments of each of 37 single-copy proteins unique to the listed Arthropod species. Bootstrap values (1,000 replicates) are indicated at each node. Substitutions per site are indicated on each branch. Isca, Ixodes scapularis, Apis, Acyrthosiphon pisum, Dnox, Diuraphis noxia, Phum, Pediculus humanus, Dmel, Drosophila melanogaster, Agam, Anopheles gambiae, Bmor, Bombyx mori, Amel, Apis mellifera. B. Comparison of gene distributions among ortholog groups: Common orthology denotes genes common to all listed species that do not follow strict 1:1:1 or N:N:N relationships among species. 1:1:1 orthologs are comprised of a single gene in all species. N:N:N orthologs are comprised of multiple genes in all species. Patchy orthologs are missing in at least one insect species. Insect-specific orthologs are present in all insect species, but absent in I. scapularis. Ixodes-specific orthologs are present only in I. scapularis. Homology denotes proteins that are assigned matches with indeterminate orthology. Undetectable similarity denotes proteins to which there is no match with an E-value < 1E−5 in the OrthoMCL database.