Expression of DEGs significant for disease-healthy contrast among health states. (A) Heatmap for top DEGs (FDR = 0.01). Rows are genes, columns are samples ordered as in the bottom panel: ahead-of-lesion (AL), healthy (H), and diseased (D). The color scale is in log2 (fold change relative to the gene’s mean). The tree is a hierarchical clustering of genes based on Pearson’s correlation of their expression across samples. (B) Principal coordinate analysis of all DEGs at 10% FDR for disease-healthy contrast.