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Figure 1 | BMC Genomics

Figure 1

From: The complete methylome of Helicobacter pylori UM032

Figure 1

Schematic representation of the specificity switching of the Type IIG MTase HpyUM032XIII. (A) The S1 and S2 subunits are separated by a homopolymeric tract of 12 G residues at the location shown by , which appears to create a natural frameshift. (B) Reducing the tract length from 12 to 11 corrects the frameshift at , thereby fusing the S1 and S2 subunits. This ‘corrected’ sequence is denoted by ‘mut’, to create fusion of S1 and S2 subunits. (C–D) Expression of individual S subunits with the RM gene shows that the S1 subunit is active in the absence of S2.

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