Figure 1

In X. tropicalis, human, and mouse, the consensus NRSE motifs share sequence similarity and the majority of the NRSE sites are farther than 20 kb from a gene, with a single copy per gene. A. Sequence logos of the consensus NRSE motif derived from 32 bona fide mouse REST target genes ([26], top panel), from 1301 human NRSE motifs ([25], middle panel), and from 742 X. tropicalis NRSE motifs (bottom panel). Arrowheads mark the differences between the Xenopus and human consensus motifs. B. In all three vertebrate genomes, ~ 65% of the motifs are located farther than 20 kb from a gene. C. 80% to 90% of the putative REST target genes in three organisms have a single NRSE motif within 100 kb of a gene.