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Figure 6 | BMC Genomics

Figure 6

From: Identification of REST targets in the Xenopus tropicalis genome

Figure 6

REST mediated repression of coding and non-coding gene expression. In neural progenitors and non-neuronal cells, REST facilitates silencing of expression by binding to highly conserved NRSE elements and recruiting co-repressors and chromatin remodeling agent to convert the topology of the local DNA to heterochromatin. During neurogenesis, REST transcription is down regulated and the protein is degraded. The absence of REST in neuronal cells allows the expression of neuron specific protein-coding genes and non-coding RNAs including micro and long non-coding RNAs.

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