Cluster analysis of the 47 AA9exp subfamilies. Cluster analysis based on the number of shared hexapeptides between each subfamily. The subfamilies that included AA9 proteins designated as enzymatically characterized in the CAZy database are indicated. Subfamilies containing C1-oxidizing LPMOs are indicated with a circle and C4-oxidizing LPMOs with a square. Subfamilies containing LPMOs that are both C1- and C4- oxidizing or with unknow mechanism are indicated with a diamond. The symbol around subfamilies with cellulose-oxidizing members is red and the symbol around subfamily 3 which contains a cellulose- and hemicellulose-oxidizing member is purple. Cluster analysis was performed as described in Methods.