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Fig. 4 | BMC Genomics

Fig. 4

From: Reference genome of wild goat (capra aegagrus) and sequencing of goat breeds provide insight into genic basis of goat domestication

Fig. 4

Unique amino acid changes in CCKA receptor (CCKAR) sequences and their roles in satiety regulation in domestic goats. (a) Alignment of CCKA receptor sequences among human (H. sapiens), cattle (B. taurus), wild goat (C. aegagrus) and dometic goat (C. hircus). Amino acids unique to domestic goats are shown. Completely identical residues in all receptor homologues are shown in white letters with black background, similar residues are shown in black letters with gray background, and distinct residues are shown in black letters with white background. (b) Transmembrane topology of CCKAR. The binding region (the third extracellular loop) affected in the domestic goat is highlighted with yellow. (c) Structural model of the third extracellular loop of CCKAR. Locations of the ligand binding loop with altered sequences in the domestic goat are shown

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