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Fig. 2 | BMC Genomics

Fig. 2

From: Genome-wide association analysis identified splicing single nucleotide polymorphism in CFLAR predictive of triptolide chemo-sensitivity

Fig. 2

Schematic representation of CFLAR gene and its splice variants. a The schematic of CFLAR gene shows all the exons and the location of rs10190751 SNP at the 3’splice site of intron 6. Presence or absence of this SNP regulates production of CFLAR-short form (CFLAR-S). Difference splice variants of CFLAR are also shown along with the isoform specific primer pair’s used in this study. b Box plot showing association of rs10190751 Splicing SNP with Triptolide LC50 in HapMap LCLs. Y-axis is Log 2 Triptolide IC50 and X-axis represents rs10190751 genotype. Box Plots show medians as a line between boxes representing the first and third quartiles; the whiskers represent the range after excluding outliers. The outliers are defined as data points that fall outside of the first and third quartiles by more than 1.5-times the interquartile range. Circles falling outside the whiskers represent outliers

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