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Table 5 Summary of 3 way integrated analysis of Gene-Expression-SNP and triptolide cytotoxicity (p < 0.0001)

From: Genome-wide association analysis identified splicing single nucleotide polymorphism in CFLAR predictive of triptolide chemo-sensitivity

Gene expression (Gene symbol) Gene description Association with total # of SNPs (p < 0.0001) Distribution of SNPs (Chr: number of SNPs) Distribution of SNPs on gene (Bold indicates Maximum number of SNPs on Gene)
AGL (Chr1) Amylo-Alpha-1, 6-Glucosidase, 4-Alpha-Glucanotransferase 27 Chr2:1 / Chr4:2 / Ch6:2 / Chr16:22 CHST5/ADAT1/GABARAPL2/LRP2/SCGN/TMEM231
ASCL4 (Chr12) Achaete-Scute Complex-Like 4 24 Chr6:5 / Chr7:1 / Ch9:1 / Chr16:2 / Chr17:3 / Chr18:12 MPG/ASXL3/ATP6V0A1/EEPD1/MPG/NAGLU
C21orf96/RUNX-IT1 (Chr21) RUNX1 Intronic Transcript 1 (Non-Protein Coding) 3 Chr5:1 / Chr9:1 / Chr13:1 PDZD2
C9orf19/GLIPR2 (Chr9) Glioma Pathogenesis-Related Protein 2 20 Chr1:2 / Chr2:6 / Chr5, 7, 11 and 14 : 1 each / Chr8:3 / Chr12:2 / Chr13:3 ARRB1 / CAPN2 / CFLAR/ TP53BP2
CRYGS (Chr3) crystallin, gamma S 41 Chr1:30 Chr2 and Chr6: 3 each Chr5:2 Chr8, 9 and 14: 1 each CAMTA1
CTSK (Chr1) Cathepsin X 19 Chr1,9 and 16:1 each/ Chr5:6/ Chr7, 10 and 17: 2 each/ Chr14: 4 each CRISPLD2/FHAD1/IDE/PTPRD/RBFOX3/SNX6/SP4
DTX1 (Chr12) deltex homolog 1 (Drosophila) 31 Chr 6:5 / Chr 9:1 / Chr 14:2 / Chr 21:23 TIAM1
FOXQ1 (Chr6) Forkhead Box Protein Q1 21 Chr 1:6 / Chr 3:10 / Chr 5 and 6:1 each / Chr 16:3 FLYWCH1/GNG4/PARK2
GABARAPL1 (Chr12) GABA(A) Receptor-Associated Protein-Like 1 7 Chr 2:5 / Chr 6 and 14:1 each STRN3
JAK1 (Chr1) Janus Kinase 1 44 Chr 1:8 / Chr 2, 3, 6 and 10:2 each/ Chr 4, 12 and 13:1 each / Chr 5:12 / Chr 8:3 / Chr 14:10 GPATCH2/ SLC6A15/ TFDP2
MAPKAPK2 (Chr1) Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 3 Chr11:2 / Chr 5:1 ARRB1/ OPCML
MGC16186 (Chr10) DPY30 Domain Containing 2 10 Chr 4:4 / Chr 7, 9 and 22:1 each / Chr 10:3 MANBA/ MYO18B
MGC16385 (Chr16) CENPB DNA-Binding Domains Containing 1 18 Chr 4:4 / Chr 5:2 / Chr 17 and 22:1 each / Chr 14:10 AGXT2L1/ GIP / ITPK1/PDE6A
MTND4 (mitochondrial) Mitochondrially Encoded NADH Dehydrogenase 16 Chr 1:8 / Chr 4, 6, 8, 9 and 14:1 each / Chr 10:3 GNG4/ GPATCH2/ SH2D4B
MTND5 (mitochondrial) Mitochondrially Encoded NADH Dehydrogenase 5 10 Chr 9 and 10:1 / Chr 14:8 PTGDR / SH2D4B
MTVR1 (Chr11) Mammary Tumor Virus Receptor Homolog 1 28 Chr 2:23 / Chr 6 and 10:1 each / Chr 7:3 NIF3L1/ C7orf42/ CFLAR/ FAM126B/NIF3L1/ORC2
MUC15 (Chr11) Mucin 15, Cell Surface Associated 16 Chr 1:8 / Chr 2:2 / Chr 9, 15 and 21:1 each / Chr 11:3 CAPN2/CGNL1/TP53BP2
MXD4 (Chr4) MAX dimerization protein 4 13 Chr 2:3 / Chr 4, 5, 10 and 17:1 each / Chr 9:2 / Chr 16:4 MPG/NPRL3/CCDC46/KANK1/USP34
NADSYN1 (Chr11) NAD Synthetase 1 38 Chr 2:32 / Chr 13:1 / Chr 16:5 ERBB4/ FHAD1/ GPATCH2
PIP5K1B (Chr9) Phosphatidylinositol 4-Phosphate 5-Kinase Type-1 Beta 75 Chr 1:2 / Chr 2: 65 / Chr 6 and 14:1 each / Chr 7:4 / Chr 13:2 NIF3L1/ ABCC4/ CFLAR/ FAM126B/ GPATCH2/NDUFB3/NIF3L1/ORC2/PPIL3/SMYD3/TSGA14
PODLX2 (Chr3) podocalyxin-like 2 44 Chr 3 and 20:1 each / Chr 11:39 / Chr 11:3 LDLRAD3
ROPN1 (Chr3) Rhophilin Associated Tail Protein 1 7 Chr 1:2 / Chr 3:3 / Chr 4 and 13:1  
SLC35D2 (Chr9) Solute Carrier Family 35 Member D2 18 Chr 4 and 10:3 each / Chr 5:10 / Chr 13 and 22:1 each ABLIM2/ MANBA/ TTLL1
TDE1 (Chr20) Tumor Differentially Expressed 1 39 Chr 1:12 / Chr 2, 10and 14:1 each / Chr 3:6 / Chr 5:9 / Chr 8:7 / Cht 15:2 FHAD1/PPCS/ SMYD3/ZMYND12
TWSG1 (Chr18) Twisted Gastrulation Protein Homolog 1 8 Chr 2:5 / Chr 6:3 CLK1/ FAM126B/
VIAAT (Chr20) Solute Carrier Family 32 Member 1 55 Chr 6 and 10:4 each / Chr 12:1 / Chr 13: 3 / Chr 14:41 / Chr 16:2 SNX6/ STRN3/ RSU1
VPS39 (Chr15) Vacuolar Protein Sorting 39 14 Chr 2, 3 and 5: 3 each / Chr 4, 11, 13, 14 and 22:1 each ACTN1/ ARRB1/ GRM7/ SEZ6L
  Total 648