Table 1 The 10 most significant genes in the AGP analysis for autism identified by the OPTPDT
| Â | Â | Â | P-value | |||
|---|---|---|---|---|---|---|
Chromosome | Gene | Number of SNPs | OPTPDT | GATES | PLINK | FBAT |
20 | MACROD2-AS1 | 16 | 2.5 × 10− 6 | 7.2 × 10− 6 | 1.5 × 10− 3 | 2.2 × 10− 2 |
1 | CYMP | 11 | 5.0 × 10− 5 | 2.8 × 10− 4 | 1.5 × 10− 3 | 3.9 × 10− 4 |
5 | CAPSL | 18 | 5.0 × 10− 5 | 1.2 × 10− 3 | 1.5 × 10− 3 | 1.1 × 10− 2 |
13 | LINC00548 | 7 | 4.0 × 10− 4 | 6.2 × 10− 3 | 2.5 × 10− 3 | 5.3 × 10− 3 |
18 | IMPA2 | 28 | 4.0 × 10− 4 | 5.4 × 10− 3 | 2.5 × 10− 2 | 1.5 × 10− 1 |
3 | GMNC | 2 | 4.0 × 10− 4 | 2.3 × 10− 4 | 2.0 × 10− 4 | 6.9 × 10− 5 |
11 | LUZP2 | 206 | 5.0 × 10− 4 | 5.2 × 10− 2 | 3.0 × 10− 1 | 6.5 × 10− 1 |
17 | KRTAP4-6 | 1 | 5.0 × 10− 4 | 1.3 × 10− 3 | 1.0 × 10− 3 | 1.7 × 10− 3 |
17 | ERN1 | 16 | 5.0 × 10− 4 | 7.1 × 10− 3 | 3.5 × 10− 3 | 2.8 × 10− 1 |
2 | IRS1 | 18 | 5.0 × 10− 4 | 1.4 × 10− 3 | 1.3 × 10− 2 | 4.7 × 10− 3 |