Skip to main content

Table 1 The 10 most significant genes in the AGP analysis for autism identified by the OPTPDT

From: A multi-SNP association test for complex diseases incorporating an optimal P-value threshold algorithm in nuclear families

    P-value
Chromosome Gene Number of SNPs OPTPDT GATES PLINK FBAT
20 MACROD2-AS1 16 2.5 × 10− 6 7.2 × 10− 6 1.5 × 10− 3 2.2 × 10− 2
1 CYMP 11 5.0 × 10− 5 2.8 × 10− 4 1.5 × 10− 3 3.9 × 10− 4
5 CAPSL 18 5.0 × 10− 5 1.2 × 10− 3 1.5 × 10− 3 1.1 × 10− 2
13 LINC00548 7 4.0 × 10− 4 6.2 × 10− 3 2.5 × 10− 3 5.3 × 10− 3
18 IMPA2 28 4.0 × 10− 4 5.4 × 10− 3 2.5 × 10− 2 1.5 × 10− 1
3 GMNC 2 4.0 × 10− 4 2.3 × 10− 4 2.0 × 10− 4 6.9 × 10− 5
11 LUZP2 206 5.0 × 10− 4 5.2 × 10− 2 3.0 × 10− 1 6.5 × 10− 1
17 KRTAP4-6 1 5.0 × 10− 4 1.3 × 10− 3 1.0 × 10− 3 1.7 × 10− 3
17 ERN1 16 5.0 × 10− 4 7.1 × 10− 3 3.5 × 10− 3 2.8 × 10− 1
2 IRS1 18 5.0 × 10− 4 1.4 × 10− 3 1.3 × 10− 2 4.7 × 10− 3