Table 1 Targets analyzed by the western-blot and the expression status (color coded) of the corresponding metastamiRs in high-risk metastatic neuroblastoma

ADAMTS-1

miR-1224-3p, miR-1260, miR-125b

ASK1

miR-1258, miR-1243, miR-519c-3p, miR-1224-5p, miR-20a, miR-93, miR-1260, miR-23a*, miR-30b*

AURK ß

miR-765

BIRC2

miR-500*

cMYC

let-7a, let-7b, let-7c, let-7e, let-7f, let-7g, miR-98

CASP8

miR-519c-3p, miR-143*, miR-20a, miR-93, miR-1224-3p

CD1C

miR-1306, miR-190, miR-190b, miR-620

CD54

miR-431*

CDK4

miR-548m, miR-765

CFOS

miR-383

PARP

miR-519c-3p, miR-766

CREB

miR-190, miR-190b, miR-1224-5p, miR-20a, miR-93, miR-125b, miR-27b

CTGF

miR-30c-1*, miR-576-3p, miR-383, miR-143*, miR-30b*

CXCR4

miR-1, miR-206

CYCLIN D1

let-7a, let-7b, let-7c, let-7e, let-7f, let-7g, miR-98, miR-383, miR-1269, miR-1, miR-206, miR-20a, miR-93, miR-23a*, miR-608

EGFR

miR-664*, miR-1250, miR-1269, miR-1, miR-206, miR-149*, miR-27b, miR-1909*, miR-608

ELK1

miR-1260, miR-125b, miR-765, miR-1321, miR-608

NOS3

miR-887, miR-1244, miR-765

ESR1

miR-188-5p, miR-190, miR-190b, miR-1182, miR-519c-3p, miR-1, miR-206, miR-148b, miR-20a, miR-93, miR-1909*

E-SELECTIN

miR-593

FOS B

miR-766, miR-1, miR-206, miR-148b, miR-1224-3p, miR-1260, miR-23a*, miR-765, miR-27b, miR-1909*, miR-608

FRA

miR-593, miR-149*

GRB10

miR-519c-3p, miR-513a-5p, miR-30b*, miR-125b

IL-1α

miR-149*, miR-30b*

JUN D

miR-1, miR-206, miR-1321

kRAS

let-7a, let-7b, let-7c, let-7e, let-7f, let-7g, miR-98, miR-1243, miR-143*, miR-513a-5p, miR-1, miR-206, miR-200b, miR-30b*, miR-27b

KRTAP1-1

miR-601, miR-1258, miR-143*, miR-23a*

MCP1

miR-664*, miR-593 , miR-1, miR-206

MEGF10

miR-190, miR-190b, miR-1258, miR-383

MMP10

miR-32*, miR-32, miR-367*, miR-148b

MMP2

miR-20a, miR-93, miR-765, miR-125b, miR-1321, miR-608

MMP3

miR-20a, miR-93

MTA2

miR-148b, miR-1321

MYB

miR-1224-5p

NF2

miR-1909*, miR-32*, miR-32, miR-367*, miR-608

GSK3B

miR-624*, miR-1, miR-206, miR-23a*, miR-27b

P38

miR-1258, miR-1243, miR-513a-5p, miR-125b, miR-27b

P21

miR-92a-2*, miR-32*, miR-32, miR-367*, miR-20a, miR-93, miR-765, miR-608

AKT2

miR-200b, miR-148b, miR-1224-3p, miR-1260, miR-1909*, miR-608

AKT3

miR-320b, miR-320c, miR-149*, miR-20a, miR-93

PKC

miR-30b*, miR-1321, miR-1909*

PTPN3

miR-593, miR-20a, miR-93, miR-765, miR-27b

SDF-1ß

miR-624*, miR-1182, miR-519c-3p, miR-1260, miR-23a*, miR-765, miR-1909*

SEMA3D

miR-432, miR-1268, miR-1321

STAT3

let-7a, let-7b, let-7c, let-7e, let-7f, let-7g, miR-98, miR-1244, miR-20a, miR-93, miR-125b, miR-1909*, miR-608

SURVIVIN

miR-1182, miR-1321

TNFR1

miR-766

TNF-α

miR-125b-1*, miR-519c-3p, miR-1909*

VEGF

miR-383, miR-1, miR-206, miR-200b, miR-20a, miR-125b, miR-27b