Fig. 4

Analysis of p53 REs found in distal DNAse hypersensitive regions. a Boxplot of the nucleotide length of human distal DNAse hypersensitive regions, determined as described in Methods. b Pie chart displaying the distribution of grades associated to REs found in human distal DNAse hypersensitive regions. c Comparison between the frequencies of REs found in human distal DNAse hypersensitive regions, and the frequencies of REs found in random sequences with the same GC content. The comparison is shown for each grade. The ratio is 1 if the frequency is the same (horizontal dotted line), > 1 if the frequency is higher in DNAse regions, <1 if the frequency is higher in random sequences. All enrichments of REs mapped to distal DNAse hypersensitive regions are highly significant (Binomial test p-value < 1E-20). d Pie charts displaying p53retriever classification on two lists of regions identified by ChIP-seq in [17] as proto-enhancers (upper panel) and enhancers (lower panel)