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Table 1 Participant characteristics by study

From: APOL1 G1 genotype modifies the association between HDLC and kidney function in African Americans

  HUFS NHAAN ARIC
  Men Women Men Women Men Women
N 486 763 220 347 690 1086
Age (yrs) 42.3 ± 12.8 41.7 ± 13.1 46.4 ± 13.7 44.9 ± 13.1 53.1 ± 5.9 52.3 ± 5.5
BMI (kg/m2) 28.7 ± 7.6 31.4 ± 8.9 29.3 ± 7.2 33.2 ± 9.0 27.3 ± 4.7 30.1 ± 6.3
African Ancestry (%) 79.9 ± 11.2 79.0 ± 11.6 79.5 ± 11.1 80.4 ± 9.8 83.0 ± 11.0 83.0 ± 10.9
rs73885319 GG (%) 21 (4.3 %) 31 (4.1 %) 25 (11.4 %) 34 (9.8 %) 9 (1.3 %) 27 (2.5 %)
HDLC (mg/dl) 50.5 ± 14.9 54.7 ± 14.9 48.1 ± 15.3 53.1 ± 16.8 51.6 ± 17.4 58.7 ± 17.1
rs71785313 −/− (%) 10 (2.1 %) 18 (2.4 %) 6 (2.7 %) 11 (3.2 %) -- --
2 APOL1 risk alleles (%)1 60 (12.5 %) 89 (12.1 %) 46 (20.9 %) 89 (25.7 %) -- --
eGFR (ml/min/1.73 m2) 106.8 ± 18.8 107.7 ± 20.9 98.6 ± 20.9 100.9 ± 21.4 78.2 ± 12.0 78.0 ± 11.9
  1. 1Individuals with either rs73885319 GG or rs71785313 −/− or heterozygous for both rs73885319 and rs71785313 (no individuals were homozygous for both rs73885319 GG and rs71785313 −/−)