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Table 2 Evaluation of the interaction between rs73885319 and HDLC on eGFR among African Americans by study

From: APOL1 G1 genotype modifies the association between HDLC and kidney function in African Americans

  rs73885319 logHDL rs73885319 × logHDL
  β (SE) P-value β (SE) P-value β (SE) P-value
HUFS, NHAAN, and ARIC combined −1.32 (1.26) 0.30 4.69 (2.08) 0.02 −37.42 (9.74) 0.0001
HUFS 0.51 (2.45) 0.83 −0.12 (4.30) 0.98 −52.12 (18.55) 0.005
NHAAN −3.73 (2.34) 0.11 7.09 (6.11) 0.25 −50.35 (18.18) 0.006
ARIC −1.84 (2.06) 0.37 8.03 (2.24) 0.0003 −10.30 (17.03) 0.55
ARIC (≤55 years) −2.17 (2.59) 0.40 7.69 (2.88) 0.008 −29.78 (21.78) 0.17
HUFS, NHAAN, and ARIC combined (≤55 years) −1.24 (1.50) 0.41 5.31 (2.54) 0.04 −49.47 (11.44) 0.00002
  1. Results are from a model of eGFR as predicted by rs73885319 × HDLC, adjusted for rs73885319, HDLC, age, BMI, sex, genome-wide proportion of African ancestry, study (where combined), and the random effect of family