Skip to main content

Table 3 Evaluation of the interaction between APOL1 risk variants and HDLC on eGFR among African Americans1

From: APOL1 G1 genotype modifies the association between HDLC and kidney function in African Americans

Ā 

APOL1 variant

logHDL

APOL1 variantā€‰Ć—ā€‰logHDL

APOL1 Variant tested

Ī² (SE)

P-value

Ī² (SE)

P-value

Ī² (SE)

P-value

rs73885319 (only)

āˆ’1.48 (1.69)

0.38

1.85 (3.53)

0.60

āˆ’44.3 (12.8)

0.0006

rs71785313 (only)

0.05 (2.58)

0.98

āˆ’0.70 (3.47)

0.84

āˆ’2.8 (22.5)

0.90

APOL1 risk genotype (both)2

āˆ’1.47 (1.12)

0.19

3.02 (3.72)

0.42

āˆ’24.1 (8.7)

0.005

  1. Results from a model of eGFR as predicted by APOL1 variantā€‰Ć—ā€‰HDLC, adjusted for variant, HDLC, age, BMI, sex, genome-wide proportion African ancestry, study, and the random effect of family. 1Data are presented for HUFS and NHAAN only, as rs71785313 was not available in ARIC; 2Individuals with either rs73885319 GG or rs71785313 āˆ’/āˆ’ or heterozygous for both rs73885319 and rs71785313 (no individuals were homozygous for both rs73885319 GG and rs71785313 āˆ’/āˆ’) compared to individuals who were heterozygous for either rs73855319 or rs71785313 or homozygous for the reference allele for both
Back to article page

BMC Genomics

ISSN: 1471-2164

Contact us