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Table 3 Selection of down-regulated genes in mouse spleens in response to MVA, LSDV, CNPV, FWPV, PEPV and FeP2. Differences in Log2 Fold Changes (between each virus and the control) are depicted

From: Six host-range restricted poxviruses from three genera induce distinct gene expression profiles in an in vivo mouse model

Symbol

Name

Entrez

MVA

LSDV

CNPV

FWPV

PEPV

FeP2

Genes down-regulated by LSDV ALONE

Adamdec1

ADAM-like, decysin 1

58860

-

−1.1

-

-

-

-

Cd59a

CD59a antigen

12509

-

−1.2

-

-

-

-

Cd7

CD7 antigen

12516

-

−1.1

-

-

-

-

Esm1

endothelial cell-specific molecule 1

71690

-

−1.1

-

-

-

-

Igfbp3

insulin-like growth factor binding protein 3

16009

-

−1

-

-

-

-

Igk

immunoglobulin kappa chain complex

243469

-

−1

-

-

-

-

Lilra5

leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5

232801

-

−1.1

-

-

-

-

Prkcg

protein kinase C, gamma

18752

-

−1

-

-

-

-

Genes down-regulated by MVA alone

Ctsf

cathepsin F

56464

−1.1

-

-

-

-

-

Depdc1a

DEP domain containing 1a

76131

−1.1

-

-

-

-

-

Diap3

diaphanous homolog 3 (Drosophila)

56419

−1.1

-

-

-

-

-

Hmmr (CD168)

hyaluronan mediated motility receptor (RHAMM)

15366

−1

-

-

-

-

-

Tlr11

toll-like receptor 11

239081

−1

-

-

-

-

-

Genes down-regulated by lsdv and MVA, BUT NOT BY CNPV and FWPV

Ccl21a

chemokine (C-C motif) ligand 21A (serine)

18829

−1.3

−1.7

-

-

-

-

Ccl21b

chemokine (C-C motif) ligand 21B (leucine)

100042493

−1.2

−1.7

-

-

-

-

Ccl21c

chemokine (C-C motif) ligand 21C (leucine)

65956

−1.2

−1.6

-

-

-

-

Kel

Kell blood group

23925

−1.5

−1.5

-

-

-

-

Slc12a2

solute carrier family 12, member 2

20496

−1

−1

-

-

-

-

Timd4

T cell immunoglobulin and mucin domain containing 4

276891

−1.1

−1.3

-

-

-

-

Genes down-regulated by CNPV, FWPV AND MVA ONLY, and not LSDV.

Tspan33

tetraspanin 33

232670

−1.6

-

−1.3

−1.1

-

-

OTHER

Abca9

ATP-binding cassette, sub-family A (ABC1), member 9

217262

−1.3

−1.5

-

−1.1

-

-

Aplnr

apelin receptor

23796

−1.4

−1.5

−1.2

−1.2

-

-

Cd209a

CD209a antigen

170786

−1.7

−2.2

−1.1

−1.5

-

-

Cd209b

CD209b antigen

69165

−1.2

−1.3

-

-

-

-

Cldn13

claudin 13

57255

−1.5

−1.2

−1.1

-

-

-

Emr4

EGF-like module containing, mucin-like, hormone receptor-like sequence 4

52614

−1.4

−1.8

−1.1

−1.5

−1.3

-

Fcamr

Fc receptor, IgA, IgM, high affinity

64435

−1.1

-

−1.5

-

-

-

Fcer2a

Fc receptor, IgE, low affinity II, alpha polypeptide

14128

−2.6

−3

−2.4

−2.5

−2.2

−1.3

H2-M2

histocompatibility 2, M region locus 2

14990

−1

−1.4

−1

−1

−1.1

-

Hs3st2

heparan sulfate (glucosamine) 3-O-sulfotransferase 2

195646

−1.4

−1.3

−1

−1

-

-

Ifi27l1

interferon, alpha-inducible protein 27 like 1

52668

−1.4

−1.3

-

-

-

-

Mgst3

microsomal glutathione S-transferase 3

66447

−1.6

−1

-

−1

-

-

Slc16a10

solute carrier family 16 (monocarboxylic acid transporters), member 10

72472

−1.4

-

-

−1.1

-

-

Slc2a4

solute carrier family 2 (facilitated glucose transporter), member 4

20528

−1.7

−1

-

−1.1

-

-

Slc38a5

solute carrier family 38, member 5

209837

−1.4

−1.2

−1

-

-

-

Slc6a20a

solute carrier family 6 (neurotransmitter transporter), member 20A

102680

−1.4

−1.3

−1

−1

-

-

Tfrc

transferrin receptor

22042

−1.2

-

-

-

-

-

Tspan8

tetraspanin 8

216350

−1.4

-

-

−1

-

-

  1. Italics genes down-regulated by LSDV alone
  2. Bold Genes down-regulated by MVA alone
  3. Underlined genes down-regulated by LSDV and MVA, but not by avipoxviruses
  4. Italics and underlined genes down-regulated by CNPV, FWPV and MVA only, and not LSDV
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BMC Genomics

ISSN: 1471-2164

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