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Table 3 Transcription factors, positively contributing to PC1. Table shows a subset of significantly contributing loci with relevant functions in skin lineage (for full data, see Additional file 11: Table S8)

From: Gene expression analysis of skin grafts and cultured keratinocytes using synthetic RNA normalization reveals insights into differentiation and growth control

Gene Symbol

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Z-score

 

HLF

1.059

3.690

Inhibitor of cell death response [PMID:23415677]

ZBTB16

1.039

3.621

 

HOPX

1.022

3.558

Controlling differentiation-dependent genes [PMID:20226564]

EGR3

0.999

3.477

 

ID4

0.986

3.436

Lack of the protein in parakeratotic cells at upper skin layer [PMID:21663940]

MNDA

0.968

3.369

 

HCLS1

0.947

3.297

 

SOX5

0.947

3.295

Genes coding SOX5 binding sites at the promoters were PC1 positive correlation (V$SOX5_01; q-value FDR ~ 0)

SOX21

0.937

3.261

Master regulator of hair shaft cuticle differentiation [PMID:19470461]

ETV7

0.928

3.227

 

POU3F1

0.920

3.200

Transactivator for FLG (a.k.a. profilaggrin; PC1 positive correlation, Local- FDR = 7.34 × 10-4; [PMID:10809764])

POU2F3

0.906

3.151

10-4; [PMID:10809764] & [PMID:7682011]); repressor for KRT14 (PC1 negative correlation, Local-FDR ~ 0; [PMID:11429405])