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Table 3 Transcription factors, positively contributing to PC1. Table shows a subset of significantly contributing loci with relevant functions in skin lineage (for full data, see Additional file 11: Table S8)

From: Gene expression analysis of skin grafts and cultured keratinocytes using synthetic RNA normalization reveals insights into differentiation and growth control

Gene Symbol Loading Z-score  
HLF 1.059 3.690 Inhibitor of cell death response [PMID:23415677]
ZBTB16 1.039 3.621  
HOPX 1.022 3.558 Controlling differentiation-dependent genes [PMID:20226564]
EGR3 0.999 3.477  
ID4 0.986 3.436 Lack of the protein in parakeratotic cells at upper skin layer [PMID:21663940]
MNDA 0.968 3.369  
HCLS1 0.947 3.297  
SOX5 0.947 3.295 Genes coding SOX5 binding sites at the promoters were PC1 positive correlation (V$SOX5_01; q-value FDR ~ 0)
SOX21 0.937 3.261 Master regulator of hair shaft cuticle differentiation [PMID:19470461]
ETV7 0.928 3.227  
POU3F1 0.920 3.200 Transactivator for FLG (a.k.a. profilaggrin; PC1 positive correlation, Local- FDR = 7.34 × 10-4; [PMID:10809764])
POU2F3 0.906 3.151 10-4; [PMID:10809764] & [PMID:7682011]); repressor for KRT14 (PC1 negative correlation, Local-FDR ~ 0; [PMID:11429405])