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Table 5 Most significant gene sets enriched in PC2 correlating genes. (a) Table is a subset of gene sets (ten out of 23) significantly (FDR q-value < 1 %) enriched in PC2 positively correlating genes, which were upregulated in EKCs, by PC-GSEA (for full data, see Additional file 10: Table S7). (b) Table is gene sets significantly enriched in PC2 negatively correlating genes, which were upregulated in HaCaTs. SIZE is number of genes belonging the gene set. NES is normalized enrichment score

From: Gene expression analysis of skin grafts and cultured keratinocytes using synthetic RNA normalization reveals insights into differentiation and growth control

Name

SIZE

NES

FDR q-val

(a)

   

PUJANA_BRCA_CENTERED_NETWORK

117

1.909

0.00492

ZHANG_TLX_TARGETS_UP

89

1.875

0.00885

BURTON_ADIPOGENESIS_PEAK_AT_16H

40

1.873

0.00590

PUJANA_XPRSS_INT_NETWORK

168

1.869

0.00467

ZHANG_TLX_TARGETS_36HR_DN

185

1.868

0.00394

EGUCHI_CELL_CYCLE_RB1_TARGETS

23

1.856

0.00476

REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM

52

1.846

0.00436

ABRAMSON_INTERACT_WITH_AIRE

44

1.845

0.00394

GOLUB_ALL_VS_AML_UP

24

1.841

0.00383

ZHANG_TLX_TARGETS_60HR_DN

275

1.839

0.00374

(b)

   

MIKKELSEN_ES_HCP_WITH_H3K27ME3

35

2.441

0.00000

REACTOME_XENOBIOTICS

15

2.345

0.00851