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Table 7 Significant gene sets enriched in PC3 correlating genes. Tables a, b and c are subsets of gene sets significantly (FDR q-value < 1 %) enriched in PC3 correlating genes by PC-GSEA (for full data, see Additional file 10: Table S7). (a) Table is a subset of the ten (out of 30) gene sets most significantly enriched in the positively correlating genes, which were upregulated in LKCs. (b) Table is cell cycle associated gene sets significantly enriched in the negatively correlating genes, which were upregulated in HaCaTs. (c) Table is miRNA-target gene sets significantly enriched in PC3 negatively correlating genes. SIZE is number of genes belonging the gene set. NES is normalized enrichment score

From: Gene expression analysis of skin grafts and cultured keratinocytes using synthetic RNA normalization reveals insights into differentiation and growth control

Name SIZE NES FDR q-val
(a)    
REACTOME_OLFACTORY_SIGNALING_PATHWAY 36 2.967 0
DAZARD_UV_RESPONSE_CLUSTER_G28 20 2.908 0
DAZARD_UV_RESPONSE_CLUSTER_G24 27 2.774 0
PID_CONE_PATHWAY 16 2.774 0
MAHADEVAN_RESPONSE_TO_MP470_DN 19 2.760 0
WANG_TNF_TARGETS 23 2.758 0
BURTON_ADIPOGENESIS_1 33 2.742 0
AMIT_EGF_RESPONSE_60_MCF10A 38 2.735 0
VOLTAGE_GATED_POTASSIUM_CHANNEL_COMPLEX 29 2.689 0
RORIE_TARGETS_OF_EWSR1_FLI1_FUSION_UP 30 2.663 0
(b)    
REACTOME_G2_M_CHECKPOINTS 41 1.865 0.00029
REACTOME_MITOTIC_PROMETAPHASE 85 1.822 0.00064
REACTOME_MITOTIC_M_M_G1_PHASES 167 1.783 0.00114
REACTOME_G0_AND_EARLY_G1 23 1.732 0.00241
REACTOME_CELL_CYCLE 392 1.710 0.00314
REACTOME_CELL_CYCLE_CHECKPOINTS 111 1.690 0.00428
REACTOME_S_PHASE 106 1.660 0.00596
REACTOME_M_G1_TRANSITION 78 1.646 0.00706
REACTOME_REGULATION_OF_MITOTIC_CELL_CYCLE 77 1.621 0.00908
(c)    
GEORGES_CELL_CYCLE_MIR192_TARGETS 62 1.726 0.00272
TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C 449 1.675 0.00501