TY - JOUR AU - Chin, Chui-Yoke AU - Hara, Yuka AU - Ghazali, Ahmad-Kamal AU - Yap, Soon-Joo AU - Kong, Cin AU - Wong, Yee-Chin AU - Rozali, Naufal AU - Koh, Seng-Fook AU - Hoh, Chee-Choong AU - Puthucheary, Savithri D. AU - Nathan, Sheila PY - 2015 DA - 2015/06/20 TI - Global transcriptional analysis of Burkholderia pseudomallei high and low biofilm producers reveals insights into biofilm production and virulence JO - BMC Genomics SP - 471 VL - 16 IS - 1 AB - Chronic bacterial infections occur as a result of the infecting pathogen’s ability to live within a biofilm, hence escaping the detrimental effects of antibiotics and the immune defense system. Burkholderia pseudomallei, a gram-negative facultative pathogen, is distinctive in its ability to survive within phagocytic and non-phagocytic cells, to persist in vivo for many years and subsequently leading to relapse as well as the development of chronic disease. The capacity to persist has been attributed to the pathogen’s ability to form biofilm. However, the underlying biology of B. pseudomallei biofilm development remains unresolved. SN - 1471-2164 UR - https://doi.org/10.1186/s12864-015-1692-0 DO - 10.1186/s12864-015-1692-0 ID - Chin2015 ER -