Fig. 1

Genetic associations with ear type and body mass among dog breeds. a Manhattan plot showing raw p-value of association with ear type (upper panel) and body mass (lower panel) among dog breeds across ~174,000 SNPs. The most significant associations with ear type are found within a region 9.5–12.5 Mb on CFA10. The most significant association with body mass is found on CFA15, close to the IGF1 gene. The CFA10 region associated with ear type is the second most strongly associated region for body mass. b Expanded view of the CFA10 region showing association with ear type (upper panel) and body mass (lower panel). c Significance of association between allele frequency and ear type (upper panel) and body mass (lower panel) at 123 candidate SNPs within a ~2 Mb region on CFA10 in 288 samples from 46 breeds. d Position of human RefSeq genes mapped onto the canFam2.0 reference. Genes are labelled +/− according to direction of transcription