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Fig. 4 | BMC Genomics

Fig. 4

From: Linked genetic variants on chromosome 10 control ear morphology and body mass among dog breeds

Fig. 4

Patterns of genetic variation and candidate SNPs. a Variation in heterozygosity within dogs and FST between wolves and dogs in a 3 Mb region on CFA10 encompassing the critical interval associated with ears and body mass. Both statistics were measured in 40 kb windows. Horizontal dotted lines represent cutoff values for percentiles across the entire genome. A region with extremely high FST and extremely low heterozygosity (11.15–11–-25 Mb) is marked by a vertical dotted line. b Detailed view of the SNPs most associated with ear type, which are clustered downstream of the MSRB3 gene and the SNPs that are fixed for alternate alleles between wolves and dogs, including a cluster of SNPs within the MSRB3 gene. The ear type associated SNPs are located at sites that map to lincRNA transcripts in the human genome, whereas the cluster of dog-wolf fixed SNPs are found in introns of MSRB3. Also shown are the GERP conserved elements derived from a 39 eutherian mammal alignment [50]

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