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Fig. 6 | BMC Genomics

Fig. 6

From: Systematically dissecting the global mechanism of miRNA functions in mouse pluripotent stem cells

Fig. 6

MiRNAs abundantly target DNA methylation systems. a, Dnmt3a was targeted by 30 up-regulated miRNAs and was ranked in the top 1 % of the up-regulated miRNA targets. The network nodes (miRNA targets) were plotted against the node degree (miRNA binding number only). b, the Dnmt3a network targeted by miR NAs. The most important miRNAs, including the miR-302-367 and miR-290-295 cluster, are found in the Dnmt3a network. c, miRNAs target another methylation enzyme Dnmt1

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