Analysis of the TGFβ-induced program in primary airway epithelial cells shows essential role of NF-κB/RelA signaling network in type II epithelial mesenchymal transition

Table 6 Significantly depleted human TFs for the upregulated genes in the EMT process

Human TFs	PMID	# total TGs	# DETGs	Fold ratio	Corrected p-value	Cell lines
ELF1	17652178	99	0	Inf	<3.45E-14	JURKAT
GABP	17652178	655	9	4.6	2.2E-08	JURKAT
EST1	17652178	636	9	4.5	6.4E-08	JURKAT
ETS1	20019798	1446	28	3.3	2.8E-14	JURKAT
KDM6A	18722178	410	9	2.9	7.4E-03	U937_AND_SAOS2
FOXP3	21729870	1300	43	1.9	6.1E-05	TREG
VDR	23849224	2029	69	1.9	9.1E-08	CD4+
GABP	19822575	2430	92	1.7	7.2E-07	HepG2
HOXC9	25013753	1858	72	1.6	1.7E-04	NEUROBLASTOMA BE2-C

The depleted transcription factors (TFs) were inferred by comparing ChIP-Seq or ChIP-chip identified target genes (TGs) of each TF with the upregulated DEGs in the EMT process. Depleted TFs were sorted according to the depleted fold ratios
PMID pubmed article number; # total TGs number of ChIP-Seq or ChIP-chip identified target genes (TGs) of each TF; #DETGs number of differentially expressed genes

ISSN: 1471-2164