Fig. 9

Pathways analysis of critical periods genes. The 16 critical periods genes from Fig. 8 were used as seeds to generate a functional association network of known and predicted interactions using the GeneMANIA tool (http://genemania.org). Analysis based on gene ontology (GO) biological function annotations. a Network generated from the 16 critical periods genes (nodes with black circles) and 50 interacting genes (nodes with gray circles). Connection type is denoted by line color (see legend), and strength (line thickness) is weighted by linear regression-based computations of the functional association data in the databases indexed. b Connections of the 13 genes (out of 66) from the entire network that were listed in the GO category: regulation of synaptic transmission. The normalized counts of these genes are plotted below. c – d Detailed connections of 2 genes from panel b: JPH3 (junctophilin-3), CSPG5 (chondroitin sulfate proteoglycan 5). See text for details