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Table 6 GSEA of selected MGI gene ontology categories

From: Transcriptional maturation of the mouse auditory forebrain

Group

Geneset

Size

FDR q-val

Direction

Synaptic plasticity regulation

[GO:0060291] Long-term synaptic potentiation

39

0.0065

UP

Synaptic plasticity regulation

[GO:0048168] Regulation of neuronal synaptic plasticity

50

0.0069

UP

Synaptic plasticity regulation

[GO:0060292] Long term synaptic depression

17

0.0070

UP

Synaptic vesicle function

[GO:0016079] Synaptic vesicle exocytosis

37

0.0075

UP

Synaptic transmission

[GO:0050806] Positive regulation of synaptic transmission

90

0.0093

UP

Synaptic vesicle function

[GO:1902803] Regulation of synaptic vesicle transport

19

0.0241

UP

Synaptic plasticity regulation

[GO:0031914] Negative regulation of synaptic plasticity

4

0.0264

UP

Synaptic transmission

[GO:0001505] Regulation of neurotransmitter levels

135

0.0514

UP

Synaptic transmission

[GO:0050805] Negative regulation of synaptic transmission

41

0.0518

UP

Synaptic transmission

[GO:0035249] Synaptic transmission

77

0.0800

UP

Dendrite development

[GO:0097062] Dendritic spine maintenance

9

0.1191

UP

Synaptic transmission

[GO:0051932] Synaptic transmission

40

0.1696

UP

Synaptic transmission

[GO:0060075] Regulation of resting membrane potential

4

0.1759

UP

Synaptic transmission

[GO:0060078] Regulation of postsynaptic membrane potential [GO:0060079] Regulation of excitatory postsynaptic membrane potential

48

0.1775

UP

Synaptic assembly maturation

Regulation of postsynaptic membrane organization [GO:1901626] and presynaptic membrane organization [GO:1901629]

6

0.2020

UP

Forebrain development

[GO:0021799] cerebral cortex radially oriented cell migration

29

0.1806

DOWN

Forebrain development

[GO:0021794] thalamus development and [GO:0061381] cell migration in diencephalon

11

0.1835

DOWN

Forebrain development

[GO:0021819] layer formation in cerebral cortex

12

0.2085

DOWN

Axon development

[GO:0048675] axon extension

60

0.2292

DOWN

Forebain development

[GO:0021978] telencephalon regionalization

13

0.2375

DOWN

  1. Geneset enrichment analysis (GSEA) of a subset of gene ontology (GO) categories in the Mouse Genome Informatics (MGI) database. From the 51 categories listed in Additional file 9: Table S24, 20 reached the FDR q-value cutoff of 0.25. For each geneset, the number of genes in the group (size), FDR q-value, and direction is given. Categories with upward (UP) and downward (DOWN) maturational trajectories were grouped separately in the Table