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Table 7 GSEA of selected HUGO gene family categories

From: Transcriptional maturation of the mouse auditory forebrain

Group

Gene family

Size

FDR q-val

Direction

Ion channels

Potassium channels (KCN)

89

0.005

UP

Receptors (neurotransmission)

Adrenergic Receptors (ADRA, ADRB)

9

0.008

UP

Structural

Lectins, sialic acid binding Ig-like (SIGLEC)

6

0.091

UP

Receptors (peptides)

VIP and PACAP (ADCYAP1) Receptors

3

0.227

UP

Ion channels

Sodium Channels (SCN)

17

0.246

UP

Structural

Collagens (COL)

43

0.000

DOWN

Structural

Kinesins (KIF)

38

0.005

DOWN

Structural (development)

Tubulins (TUBA)

17

0.031

DOWN

Structural

Extracellular matrix proteoglycans

25

0.072

DOWN

Structural

Major cadherins

31

0.075

DOWN

Structural

Protocadherins; non-clustered protocadherins

11

0.090

DOWN

RECEPTORS (peptides)

Vasopressin/oxytocin receptors

4

0.091

DOWN

Structural (development)

Caspases (CASP)

9

0.091

DOWN

Endogenous ligands

ADAM metallopeptidases thrombospondin type 1 (ADAMTS)

19

0.091

DOWN

Structural (development)

Ephrins (EFN)

8

0.094

DOWN

Receptors (other)

Prostanoid receptors

8

0.098

DOWN

Structural

Cadherin-related

16

0.099

DOWN

Structural (development)

EMI Domain Containing (EMID)

7

0.102

DOWN

Receptors (peptides)

Neuropeptide Receptors :

9

0.103

DOWN

Structural (development)

Mex-3 Homologs (MEX3)

4

0.103

DOWN

Receptors (others)

Ephrin Receptors (EPH)

14

0.167

DOWN

Ion channels

Acid-Sensing (Proton-Gated) Ion Channels (ASIC)

4

0.169

DOWN

Ion channels

Chloride Channels (Voltage Sensitive)(CLCN)

8

0.173

DOWN

Receptors (others)

Calcium-Sensing Receptors (CASR)

2

0.186

DOWN

Structural

Cell Surface Proteoglycans

13

0.190

DOWN

Receptors (peptides)

Hypocretin (OREXIN) Receptors (HCRTR)

2

0.195

DOWN

Structural

Dyneins, Axonemal (DN)

14

0.205

DOWN

  1. Geneset enrichment analysis (GSEA) of a subset of gene families in the HUGO database. From 111 categories listed in Additional file 9: Table S22, 27 families reached the FDR q-value cutoff of 0.25. For each gene family, the number of genes in the group (size), FDR q-value, and direction of expression (up, down) are listed. Categories with upward (UP) and downward (DOWN) maturational trajectories were grouped separately in the Table