An efficiency analysis of high-order combinations of gene–gene interactions using multifactor-dimensionality reduction

Table 2 Analysis results of the chronic dialysis data sets from MDR and FMDR

Models	Method	3-loci		4-loci		5-loci		6-loci
Models	Method	MDR	FMDR	MDR	FMDR	MDR	FMDR	MDR	FMDR
Best
Candidate model		40,56,64	40,56,64	21,59,64,71	21,59,64,71	21,59,62, 64,71	21,59,62, 64,71	21,45,59, 62,64,71	21,45,59, 62,64,71
Consistency		2 / 10	2 / 10	4 / 10	2 / 10	1 / 10	1 / 10	2 / 10	3 / 10
Accuracy		0.56	0.56	0.58	0.58	0.58	0.58	0.60	0.60
OR (95 % CI)		1.79	1.79	1.91	1.91	2.13	2.13	2.30	2.30
OR (95 % CI)		(1.27–2.52)	(1.27–2.52)	(1.38–2.63)	(1.38–2.63)	(1.54–2.94)	(1.54–2.94)	(1.66–3.18)	(1.66–3.18)
Worst
candidate model		45,56,62	45,56,65	40,45,56,62	19,21,34, 56	41,43,45, 56,62	40,56,64, 71,77	4,21,56, 60,62,70	40,21,56, 64,71,77
Consistency		1 / 10	1 / 10	2/10	1/10	1 / 10	1 / 10	1 / 10	1 / 10
Accuracy		0.56	0.56	0.57	0.56	0.57	0.57	0.58	0.59
OR (95 % CI)		1.64	1.65	1.82	1.78	1.86	1.90	2.13	2.28
OR (95 % CI)		(1.18–2.27)	(1.19–2.31)	(1.31–2.54)	(1.27–2.49)	(1.34–2.60)	(1.36–2.64)	(1.50–3.03)	(1.59–3.26)
Accuracy
Mean (SD)		0.56 (±0.00)	0.56 (±0.00)	0.58 (±0.01)	0.58 (±0.01)	0.58 (±0.002)	0.58 (±0.002)	0.60 (±0.01)	0.60 (±0.01)
P-value¹		−²		0.07		0.32		0.85
OR
Mean (SD)		1.73 (±0.05)	1.73 (±0.05)	2.04 (±0.19)	2.03 (±0.19)	2.21 (±0.18)	2.17 (±0.19)	2.31 (±0.08)	2.30 (±0.08)
P-value		0.66		0.44		0.03		0.46
Power
Mean (SD)		0.97 (±0.03)	0.99 (±0.02)	0.99 (±0.02)	0.99 (±0.02)	0.99 (±0.003)	0.99 (±0.002)	0.99 (±0.004)	0.99 (±0.003)
P-value		<0.001		0.83		0.71		<0.001

¹ P-value were estimated from pairwise t-test; ²-: the same accuracies between MDR and FMDR

ISSN: 1471-2164