Table 1 Examples of the clustered disconnected genes and their probable pathways. The pathways were identified using KEGG [41]. The genes are members of first bicluster of the analysis starting with in vitro data. The compounds in first bicluster are sulindac, naphthyl isothiocyanate, diclofenac and colchicine
From: Identification of in vitro and in vivo disconnects using transcriptomic data
Pathway | Genes |
|---|---|
Complement and coagulation cascades | A2m C1s C5 C8a C4bpb Cfh F5 |
Chemical carcinogenesis | Cyp1a1 Gstm3 Gsta5 |
Metabolism of xenobiotics | Akr7a3 Cyp1a1 Gstm3 Gsta5 |
Pathways in cancer | Ccnd1 Fn1 Lamc2 |