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Fig. 3 | BMC Genomics

Fig. 3

From: Identification of sequences common to more than one therapeutic target to treat complex diseases: simulating the high variance in sequence interactivity evolved to modulate robust phenotypes

Fig. 3

High variance in the interactivity of sequences facilitates the recruitment of multispecific regulators. (a) Average ratio of dinucleotide frequencies with the same base composition observed in species of different complexities. (b) Human sequences in the 3’UTR have a very similar nucleotide composition to the rest of the genome in comparison with the 5’UTR, increasing the likelihood of interactions with other sequences by complementarity. (c) Relative proportion per nucleotide of the common nucleotide sequences targeting genes of therapeutic interest identified in this work (considering the average nucleotide size of the 5’UTR, coding sequence and 3’UTR as 200, 1340 and 800 bp, respectively). Error bars are contained in data points in (A) and (B) and represent 95 % confidence intervals (binomial distributions) in comparison with random expectations. Horizontal lines represent ratio 1:1, i.e., no bias. Ec (Escherichia coli CFT073), At (Arabidopsis thaliana), Ce (Caenorhabditis elegans), Dm (Drosophila melanogaster), Mm (Mus musculus), Hs (Homo sapiens)

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BMC Genomics

ISSN: 1471-2164

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