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Table 2 Peptide sequences present in multiple proteins involved in particular human diseases. These peptides could be used as decoys, antigens to raise antibodies, or if aiming to intracellular targets delivered directly in the format of stapled peptides, incorporated as loops into naturally occurring cyclic peptides, or used after conjugation with molecules that aid in cellular uptake. Additional sequences can be found in Table S2 will be updated at www.wikisequences.org

From: Identification of sequences common to more than one therapeutic target to treat complex diseases: simulating the high variance in sequence interactivity evolved to modulate robust phenotypes

Sequence

Targets

 

Cancer

ILLLDEATSALDTESE.

ABCB1 e&i ,ABCB4 i ,ABCB11 i .

KVLGSGAFGTVYKG.

EGFR i ,ERBB2 i ,ERBB4 i .

KVAVKMLKS.

CSF1R i ,FGFR1 i ,PDGFRB i

VHRDLAARNVLV.

CSK i ,EGFR e ,EPHA8 i ,ERBB2 e ,

 

ERBB4 e ,FLT3 e ,JAK1 i ,SRMS i .

RIYTHQSDVWSYGVT

ERBB3 e ,EGFR e .

VWELMTFG.

 

YQLYSRTSGKH.

FGF8 e ,FGF17 e ,FGF18 e .

PSQRPTFKQLVEDLDR.

FGFR1 i ,FGFR2 i ,FGFR3 e .

ERSPHRPILQAGLPAN.

FGFR1 e ,FGFR2 e ,FGFR3 e ,FGFR4 e .

MEKKLHAVPA.

FGFR1 e ,FGFR4 e .

SEMEMMKMIGKHKNII

FGFR1 i ,FGFR2 i ,FGFR3 i .

NLLGACTQ.

 

THQSDVWSF.

FGFR1 i ,FGFR2 i ,FGFR3 e ,FGFR4 e .

KCIHRDLAARNVLVT

FGFR1 i ,FGFR3 e ,FGFR4 i .

EDNVMKIADFGLAR.

 

FSVLYTVPAT.

FZD1 t ,FZD2 t ,FZD4 t ,FZD7 t ,

 

FZD10 t .

YPERPIIFLS.

FZD1 i ,FZD2 e ,FZD4 t ,FZD5 e ,FZD7 e ,

 

FZD8 i ,FZD9 t ,FZD10 i .

FLALDLGGTNFRVL.

HK1 i ,HK2 i ,HK3 i ,HKDC1 i.

QLELPVKYA.

ITGAm e ,ITGAD e ,ITGAx e .

LLCDKVQKDDIEVRF.

REL i ,NFKB1 i ,NFKB2 i .

 

Immunological diseases

LCLEERDWLPG.

TLR7 i ,TLR9 i .

GLFWANLRAAIN.

TRL1 i ,TRL6 i ,TRL10 i .

IEKSYKSIFVL.

TRL1 i ,TRL6 i ,TRL10 i .

  1. eextracellular, iinternal, ttransmembrane site, bold: repeated motif