Fig. 2
From: Transcriptome sequencing of microglial cells stimulated with TLR3 and TLR4 ligands
Differential gene expression and downstream effect analysis of genes overexpressed in microglia upon TLR3 and TLR4 stimulation at two different time points. a Heat map representing RNA-seq gene expression of top 150 up-regulated inflammatory genes at 2 and 4 h after Poly (I:C) and LPS stimulation in BV-2 microglia cells compared with controls. P <0.001, fold change ≥1.5 log2 for the significant determination of DEGs. Each row shows the relative expression level for a single gene, and each column shows the expression level of a single sample. Yellow represents genes with increased expression, and green represents genes with decreased expression. b and c Gene Ontology analysis of functional annotations (biological process) associated with Poly (I:C) and LPS-inducible up-regulated genes in BV-2 microglia in comparison with the control