Fig. 3
From: Transcriptome sequencing of microglial cells stimulated with TLR3 and TLR4 ligands
Top IPA-based network involved in infectious diseases and canonical pathway analyses at 4 h after TLR3 and TLR4 stimulation. a, b Ingenuity® Bioinformatics pathway analysis of gene networks displaying interactions between infectious disease-related genes that were differentially expressed at 4 h after Poly (I:C) and LPS stimulation. Genes in white circles were not in our DEG dataset but were inserted by IPA because these genes are connected to this network. The activity of molecules highly connected to this network, namely, NF-κB2, STAT2, and IRF1 (hubs), was assessed using the IPA molecule activity predictor. c, d The most highly represented canonical pathways for differentially expressed genes in BV-2 microglial cells after Poly (I:C) and LPS stimulation