Table 3 Leads to activation of inflammatory genes by identified TFs in response to TLR4 stimulation
From: Transcriptome sequencing of microglial cells stimulated with TLR3 and TLR4 ligands
IRF7 predicted to be activated (43 genes) (p = 3.25 e-38) | STAT1 predicted to be activated (36 genes) (p = 3.02 e-32) | NFKBIA predicted to be activated (35 genes) (p = 5.88 e-25) | IRF1 predicted to be activated (20 genes) (p = 1.10 e-14) | CEBPD predicted to be activated (11 genes) (p = 1.22 e-10) |
|---|---|---|---|---|
USP18, XAF1, UBA7, TRIM5, TRIM30A, TRIM21, TREX1, TAP2, TAP1, STAT2, STAT1, SAP30, RSAD2, PHF11, PELI1, PARP14, PARP12, OASL2, OASL, OAS3. OAS2, OAS1, MX1/MX2, ISG15, IRGM1, IRGM, IRF9, IRF1, IRF7, IGTP, IFIT2, IFIT1B, IFIH1, IFI16, HELZ2, DHX58, DAXX, CXCL10, CMPK2, CCRL2, CASP4, ADAR, TLR8 | USP18, TRAFD1, TNF, TAP1, STAT2, STAT1, SOCS3, SLFN5, SLFN2, SLFN13, SLFN12L, RSAD2, PTGS2, OASL, NEURL3, MX1/MX2, ISG15, IRGM1, IRG1, IRF9, IRF1, IRF7, IGTP, IFIT2, IFIT1B, IFI16, ICAM1, HERC6, EIF2AK2, CXCL10, CMPK2, CDKN1A, CD274, CD14, CCRL2, CASP4, C3, APOBEC3B, | TNFRSF1B, TNFAIP3, TNFAIP2, SOCS3, SLFN2, SAA3, RASA3, PTGS2, NFKBIE, NFKB2, NFKB1, JUNB, ISG15, IRG1, IRF1, IL1RN, IL1A, IFIT1B, IFI16, ICAM1, HMOX1, HLA-A, GCH1, CP, CFLAR, CEBPD, CEBPB, CCL9, CCL7, CCL2, CCL3L3, CASP4, BTG2, AMPD3, CXCR4 | TRIM21, TNF, TLR3, TAP1, TAP2, STAT2, STAT1, RSAD2, PTGS2, OAS1, ISG15, IRF9, IRF7, IL1B, IL18, IFIT2, IFIH1, EIF2AK2, CXCL10, CDKN1A, | TNF, SAA3, PTGS2, PAX3, IKBKE, HP, CEBPB, CD14, CCL3, CCL2, C3 |