Fig. 6
From: Protein functional features are reflected in the patterns of mRNA translation speed
Schema of the methodology used for studying the relationship between mRNA local features and functional/structural features of the encoded proteins. For a given Uniprot FT feature (purple), all its instances in the proteome are aligned respect to the first residue. This determines an equivalent alignment of the corresponding mRNA coding regions (red lines) and their associated feature profiles (secondary structure, ribosome occupancy or tRNA concentration –black curves-). These profiles are averaged and visualized to represent the behaviour of a particular mRNA property in the neighbourhood of that FT feature (bottom left). Additionally, a distribution with the values of pair-wise correlations between these profiles is generated and compared with an equivalent distribution generated from profiles of the same size randomly taken from the proteome (bottom right)