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Fig. 6 | BMC Genomics

Fig. 6

From: Common and specific downstream signaling targets controlled by Tlr2 and Tlr5 innate immune signaling in zebrafish

Fig. 6

Specific and common responses to Tlr2 and Tlr5 ligands. The whole organism transcriptome response of zebrafish embryos to treatment with the Tlr2 ligand Pam3CSK4 or the Tlr5 ligand flagellin results in the induction of specific and common transcription factor genes as indicated in the figure. The common transcription factor genes (in cooperation with other non-inducible factors, e.g. of the NF-κB family), likely function upstream of the effector genes commonly induced by Pam3CSK4 and flagellin. The transcription factor genes induced by only one of the two ligands are likely to contribute to further specificity in the transcriptional responses of downstream effector genes

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