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Table 2 Top downregulated genes after optic nerve crush

From: Integrated analyses of zebrafish miRNA and mRNA expression profiles identify miR-29b and miR-223 as potential regulators of optic nerve regeneration

Ensembl ID Gene symbol Gene name Fold change Adjusted p-value GO process or functiona
ENSDART00000055936 isl2b islet2b 0.18 0.000315 DNA-dependent transcription
ENSDART00000137322 kcnip3 Kv channel interacting protein 3, calsenilin 0.29 0.000151 Potassium channel activity; neuronal apoptotic processes
ENSDART00000051693 irx4a Iroquois homeobox protein 4a 0.15 0.002945 DNA-dependent transcription
ENSDART00000082745 emb Embigin 0.26 0.001049 Cell adhesion; integral to membrane functioning
ENSDART00000090267 scn4ba Sodium channel, voltage-gated, type IV, beta a 0.28 0.000848 Voltage-gated sodium channel activity
ENSDART00000052338 irx4b Iroquois homeobox protein 4b 0.24 0.001560 DNA-dependent transcription
ENSDART00000052802 calb2b Calbindin 2b, (calretinin) 0.26 0.001408 Calcium ion binding; neuronal excitability
ENSDART00000027398 kcna2 Potassium voltage-gated channel, Shaker-related subfamily, member 2 0.33 0.000641 Potassium ion transport; synaptic transmission
ENSDART00000067514 rbpms2a RNA binding protein with multiple splicing 2a 0.36 0.000558 Nucleotide binding
  Unknown Unknown 0.44 0.000407  
ENSDART00000018351 zgc:65851 Paralog of internexin neuronal intermediate filament protein, alpha 0.28 0.001732 Neurofilament cytoskeleton organization
ENSDART00000134832 rbpms2b RNA binding protein with multiple splicing 2b 0.42 0.000690 Nucleic acid binding
ENSDART00000114765 kcnd1 Potassium voltage-gated channel, Shal-related subfamily, member 1 0.42 0.000917 Potassium ion transport; synaptic transmission
ENSDART00000113796 cacnb3b Calcium channel, voltage-dependent, beta 3b 0.42 0.001316 Calcium ion transmembrane transport
ENSDART00000064012 ca4a Carbonic anhydrase IV a 0.52 0.000690 Carbonate dehydratase activity; zinc ion binding
ENSDART00000113081 gpr158 G-protein coupled receptor 158 0.51 0.000947 G-protein coupled receptor activity
ENSDART00000124112 pou4f2 POU domain, class 4, transcription factor 2 0.30 0.006744 DNA-dependent transcription
ENSDART00000031167 tfap2d Transcription factor AP-2 delta 0.43 0.001926 DNA-dependent transcription
ENSDART00000031091 vsnl1a Visinin-like 1a 0.45 0.001678 Calcium ion binding
ENSDART00000077838 ryr3 Ryanodine receptor 3 0.51 0.001445 Calcium ion transmembrane transport
ENSDART00000098599 si:ch211-151 h10.2 Uncharacterised protein 0.44 0.002573  
ENSDART00000127084 LOC100537452 Uncharacterized protein 0.45 0.002423  
ENSDART00000084303 kcnq3 Potassium voltage-gated channel, KQT-like subfamily, member 3 0.45 0.002495 Potassium ion transport; synaptic transmission
ENSDART00000055281 kcnc3b Potassium voltage-gated channel, Shaw-related subfamily, member 3b 0.53 0.001560 Potassium ion transport; synaptic transmission
ENSDART00000126365 smoc1 SPARC related modular calcium binding 1 0.41 0.004141 Extracellular matrix; calcium ion binding
ENSDART00000090092 ank1 Ankyrin 1, erythrocytic 0.43 0.003530 Cytoskeletal adaptor activity
ENSDART00000023562 syt2 Synaptotagmin 2 0.50 0.002264 Calcium ion binding; synaptic transmission
ENSDART00000105932 si:dkeyp-110e4.11 Uncharacterised protein 0.43 0.004012  
  1. Ranked by combined –log10 p-value and ≥1.5 absolute fold change
  2. aGO terms determined by ZFIN and Uniprot databases
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BMC Genomics

ISSN: 1471-2164

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