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Table 2 Performance evaluation of MAC on 10 TCGA tumor samples (LUSC)

From: MAC: identifying and correcting annotation for multi-nucleotide variations

Sample barcode

Num. of input SNVs

Num. of BMs

Size of the largest BM

No Annotation

Annovar

VEP

Snpeff

Memory (Kb)

Run time (min:sec)

Num. of BMCs

Memory (Kb)

Run time (min:sec)

Num. of BMCs

Memory (Kb)

Run time (min:sec)

Num. of BMCs

Memory (Kb)

Run time (min:sec)

TCGA-18-3409-01A-01D-0983-08

3910

303

4

1123088

02:18.1

108

5185632

01:47.5

108

6701680

10:08.5

112

13766144

05:00.4

TCGA-22-5473-01A-01D-1632-08

944

21

3

652336

01:05.9

6

5180416

01:10.1

6

5017200

02:35.5

6

13654800

04:10.1

TCGA-33-4566-01A-01D-1441-08

1451

41

3

844304

01:23.5

18

5180864

01:29.0

20

5020896

03:20.2

19

13706992

04:27.2

TCGA-34-5231-01A-21D-1817-08

743

15

4

459488

00:53.8

7

5180416

00:58.6

7

5015952

02:12.6

7

13635536

03:55.1

TCGA-37-5819-01A-01D-1632-08

839

31

2

380144

00:41.0

10

5184032

00:44.1

11

5013136

02:29.6

12

13725376

03:55.3

TCGA-39-5031-01A-01D-1441-08

754

22

3

549296

00:52.5

1

5180384

00:59.2

1

5018256

02:21.9

1

13644784

03:58.5

TCGA-46-3769-01A-01D-0983-08

1037

29

3

446448

00:41.8

13

5184032

01:04.3

13

5025968

02:26.0

13

13639456

03:49.8

TCGA-60-2698-01A-01D-1522-08

1396

34

5

1198992

02:07.6

4

5180400

02:07.2

4

5021424

03:33.8

4

13715488

04:54.1

TCGA-66-2785-01A-01D-1522-08

1338

44

3

1101216

01:56.5

4

5180848

01:54.0

4

5025424

03:33.9

4

13731600

04:53.6

TCGA-85-6561-01A-11D-1817-08

984

14

2

602112

00:44.0

3

5180400

01:31.6

3

5016176

02:26.3

3

13637520

04:09.9

  1. Num. of input SNVs: the number of somatic SNVs from TCGA data matrix
  2. Num. of BMs: the number of identified Blocks of Mutations
  3. Size of the largest BM: the maximu number of SNVs in a Block of Mutations
  4. Num. of BMCs: the number of BMCs (Block of Mutations wtihin Codon)
  5. Memory: the peak memory used during the run
  6. Run time: the eclipsed wall time for the run