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Fig. 6 | BMC Genomics

Fig. 6

From: Cell cycle control, DNA damage repair, and apoptosis-related pathways control pre-ameloblasts differentiation during tooth development

Fig. 6

Hub gene selection and gene ontology analysis of brown and blue modules. a and b are the scatterplots between module membership measure (x-axis) and the gene significance of the “brown” and “blue” module. The top 20 genes with both the highest gene significance and membership measure larger than 0.9 were chosen as “hub genes”, and they are annotated with their gene symbols. The grey dashed line in the plot is the threshold for choosing significantly expressed genes, and the threshold value is –log10(0.05). c and d are the hub gene network visualizations for the “brown” and “blue” modules. The colors of the hub genes and their directly connected genes indicate the GO terms from Fig. 5 (a) and (b). e. Barplots represent enriched GO terms of all genes included in the “brown” (left with brown color) and “blue” (right with blue color) networks, and –log2(p-value) represents the relative enrichment of each GO term

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