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Table 4 Gene Ontology enrichment (Molecular Function) of predicted marker genes for the examined tissues

From: MGFM: a novel tool for detection of tissue and cell specific marker genes from microarray gene expression data

GO ID

GO

p-value

Expected count

Gene count

Size

Midbrain

GO:0008017

microtubule binding

1.02×10−11

14.02

43

148

GO:0030695

GTPase regulator activity

2.51×10−07

39.97

73

422

GO:0005525

GTP binding

4.18×10−06

31.73

58

335

GO:0030276

clathrin binding

4.27×10−06

1.89

10

20

GO:0017075

syntaxin-1 binding

5.28×10−06

1.23

8

13

Heart atrium

GO:0008307

structural constituent of muscle

3.12×10−24

1.73

25

44

GO:0003779

actin binding

2.81×10−21

13.63

58

346

GO:0005523

tropomyosin binding

1.34×10−08

0.55

8

14

GO:0051371

muscle alpha-actinin binding

2.46×10−08

0.28

6

7

GO:0031432

titin binding

4.07×10−08

0.43

7

11

Kidney cortex

GO:0008509

anion transmembrane transporter activity

4.9×10−16

8.77

40

226

GO:0015294

solute:cation symporter activity

8.98×10−11

3.03

19

78

GO:0015081

sodium ion transmembrane transporter activity

4.5×10−09

4.58

21

118

GO:0015297

antiporter activity

1.92×10−08

2.17

14

56

GO:0019534

toxin transporter activity

1.39×10−04

0.31

4

8

Liver

GO:0004497

monooxygenase activity

2.23×10−20

4.95

34

87

GO:0009055

electron carrier activity

4×10−20

8.20

43

144

GO:0048037

cofactor binding

1.17×10−16

14.11

52

248

GO:0020037

heme binding

2.06×10−15

6.83

34

120

GO:0005506

iron ion binding

1.53×10−14

8.54

37

150

Lung

GO:0005102

receptor binding

3.30×10−10

71.09

124

1129

GO:0004896

cytokine receptor activity

5.12×10−09

5.23

22

83

GO:0003823

antigen binding

1.78×10−08

3.02

16

48

GO:0019899

enzyme binding

6.89×10−07

69.58

110

1105

GO:0032395

MHC class II receptor activity

1.54×10−06

0.5

6

8

  1. Column labels are as follows: GO ID is the GO identifier; GO is the description of the GO term; p-value is the hypergeometric p-value for over-representation of each GO term; Expected/Gene Count are the expected and actual gene counts; and Size is the number of genes within each GO term