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Fig. 3 | BMC Genomics

Fig. 3

From: Distinct polymer physics principles govern chromatin dynamics in mouse and Drosophila topological domains

Fig. 3

Fitting the statistical helix model to contact frequencies quantified in mouse H1 TKO ESC. Quantitative 3C data were obtained from mouse ESC that are Triple Knock-Out for Histone H1 genes (H1 TKO), for five gene-rich TADs (a), two gene-poor TADs (b) and one gene-desert TAD (c). The graphs show the best-fit analyses obtained with the unconstrained chromatin model [eqs. 1 and 2] (black curves) or the statistical helix model [eqs. 1 and 3] (red curves). The data (see Additional file 8) were analyzed and are depicted as described in the legend of Fig. 2. Best-fit parameters, and the genomic distance contained within one statistical helix turn (Sh in kb), are given in the lower part of Table 1

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BMC Genomics

ISSN: 1471-2164

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